ANCA-negative pauci-immune rapidly progressive glomerulonephritis after COVID-19 – a case report

Abstract

Introduction: Rapidly progressive glomerulonephritis is a rare clinical condition characterised by rapid loss of renal function over a short period of time, nephritic syndrome, and crescents in renal biopsy. Pauci-immune rapidly progressive glomerulonephritis is usually associated with vasculitis, therefore skin, joints, lungs and nervous system may be involved. Numerous cases of pauci-immune rapidly progressive glomerulonephritis related with COVID-19 vaccines have been described in the literature, but there is little data on its occurrence after COVID-19 infection. Case description: We present a case of a 61-year-old female patient who was diagnosed with ANCA-negative pauci-immune rapidly progressive glomerulonephritis with nervous and respiratory system involvement within 5 months from COVID-19 infection. Conclusions: Pauci-immune rapidly progressive glomerulonephritis might be triggered by SARS-CoV-2 infection.